ISSN 1662-4009 (online)

ey0016.2-13 | Maternal Obesity and Long-term Infant Consequences | ESPEYB16

2.13. Maternal obesity and the human milk metabolome: associations with infant body composition and postnatal weight gain

E Isganaitis , S Venditti , TJ Matthews , C Lerin , EW Demerath , DA Fields

To read the full abstract: Am J Clin Nutr. 2019 Apr 4The study analyzed relationships between maternal obesity and human milk metabolites, infant body composition, and postnatal weight gain.Maternal obesity is one of the strongest predictors of childhood obesity. Although the mechanism/s by which this obesity risk is transmitted to the offspring are not known diffe...

ey0016.1-4 | New Mechanisms | ESPEYB16

1.4. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

CB Herber , WC Krause , L Wang , JR Bayrer , A Li , M Schmitz , A Fields , B Ford , Z Zhang , MS Reid , DK Nomura , RA Nissenson , SM Correa , HA Ingraham

To read the full abstract: Nat Commun 2019;10:163.Central estrogen signaling via estrogen receptor alpha (ERα) coordinates energy expenditure, reproduction and, in concert with peripheral estrogen, impacts skeletal homeostasis. Here, the authors showed that eliminating ERα in kisspeptin arcuate nucleus neurons resulted in high bone mass phenotype in female mice only.<p clas...